![]() That distinct mechanisms must exist to support growth in small and large neurons however, whether neurons with extreme growth Given this enormous range in cell size, it seems likely Likewise, dendrite arbor size scales with increased body size for many types of neurons across phylogeny ( Purves and Lichtman 1985) thus, neurons in larger animals must support greater growth demands. Of magnitude longer than dendrites of nearby granule cells ( Fiala et al. For example, mature cerebellar Purkinje neurons have dendrites that are more than two orders Within the nervous system, different types of neurons have different growth requirements, depending on the size and complexity For example, many types of sensory neurons are born early and must growĬontinuously during animal development to maintain coverage of a growing receptive field ( Bloomfield and Hitchcock 1991 Parrish et al. Growth largely entails the growth of existing cells. How cells achieve their correct size and how this relates to organ size control are fundamental, unresolved questions in biology.Īs animals grow, most tissues scale proportional to animal growth by the addition of new cells. With large dendrite arbors and define Path as a founding member of this growth program. Altogether, our results demonstrate that specialized molecular mechanisms exist to support growth demands in neurons Although Path is broadly expressed in neurons and nonneuronal cells, mutation of path impinges on nutrient responses and protein homeostasis specifically in neurons with large dendrite arbors but not in otherĬells. ![]() This mutant disrupts a putative amino acid transporter, Pathetic (Path), that localizes to the cell surface and endolysosomalĬompartments in neurons. ![]() With large dendrite arbors without affecting dendrite growth in neurons with small dendrite arbors or the animal overall. From this screen, we identified a mutant that selectively affects dendrite growth in neurons To address this question, we conducted a genetic screen for mutations that differentially affected growth in neurons withĭifferent-sized dendrite arbors. However, whether neurons with large dendrite arbors have specialized mechanisms to support their growth demands is unknown. Dendrites exhibit enormous diversity in form and can differ in size by several orders of magnitude even in a single animal. ![]()
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